Efficacy of Narrow Band Spectrum Endoscopy for the Diagnosis of Gastric Antral Vascular Ectasia in Patients With Liver Cirrhosis

Alexandria University

Status: Completed

Conditions: Gastric Antral Vascular Ectasia

Treatments: Diagnostic Test: Upper gastrointestinal endoscopy and biopsy

Study type: Observational

Funder types: Other

Identifiers

NCT04388150

0201288

Details and patient eligibility

About

the study aims to evaluate the role of similar technology of Narrow Band Imaging VIST video intelligent staining technology in the diagnosis of Gastric Antral Vascular ectasia in cirrhotic patients

Full description

VIST (Video intelligent staining technology) is used to the diagnosis of GAVE as the form of ectatic vessels in the antrum in instead of erosions in the antrum by White light endoscopy which can mislead the diagnosis to Portal hypertension gastropathy. Targeted biopsies are taken and examined histopathologically in order to see if matching with VIST view. In addition, CD61 is used to highlight the diagnosis for more confirmation. CD61 is an immunohistochemistry platelets marker.

Enrollment: 50 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with mucosal vascular lesions at the gastric antrum suspicious of GAVE of a linear striped form or a diffuse punctate form upon conventional WLE

Exclusion criteria

• Connective tissue disorders like systemic sclerosis.
• Chronic kidney disease.
• Recent use of proton pump inhibitors in the last 14 days.
• History of gastric surgery or gastric cancer.
• Pernicious anemia.
• Recent history of non-steroidal anti-inflammatory drugs intake