Efficacy of Non Contrast DWI(Diffusion Weighted Imaging) Imaging Compared to DMR-DE

University of Michigan

Status: Completed

Conditions: Heart Attack

Treatments: Procedure: Diffusion Weighted Imaging with MRI scans

Study type: Interventional

Funder types: Other

Identifiers

NCT01820000

HUM00032804

Details and patient eligibility

About

Use of MRI and DWI to diagnose cardiac scarring after heart attack.

Full description

To discover new information about MRI (magnetic resonance imaging) called DWI (diffusion weighted imaging) and its ability to diagnose cardiac scarring.

CMR-DE (cardiac MR with delayed contrast enhancement) evaluates if there has been scarring in the heart muscle following a heart attack.

Subjects are injected with a contrast medication that makes the scarring visible if present. To prove the efficacy of DWI (diffusion weighted imaging) to provide the same images that CMR-DE (cardiac magnetic resonance with delayed contrast enhancement) provides.

Enrollment: 23 patients

Sex: All

Ages: 21+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Males and females 21 years of age and older
• Healthy volunteers
• subjects with a prior history of heart attack and prior CMR-DE imaging.

Exclusion criteria

• Women who are pregnant
• Subjects with GFR < 60 ml/min/1.73m2
• Subjects with ICD
• Subjects with coronary stents incompatible with 3T

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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23 participants in 1 patient group

Diffusion Weighted Imaging with MRI scans

Experimental group

Description:

Subjects will undergo a MRI (magnetic resonance imaging) scan where DWI (diffusion weighted imaging) will be performed. Subjects will not receive contrast during this sequence, but will receive contrast as standard MRI protocol.

Treatment:

Procedure: Diffusion Weighted Imaging with MRI scans