Efficacy of Novel Titania Nanoparticles Enriched Mouth Wash in Treating Dentine Hypersensitivity

Pakistan Institute of Medical Sciences

Status

Completed

Conditions

Dentine Hypersensitivity

Treatments

Procedure: Group-B Novel Titania nanoparticles enriched Mouth Wash

Procedure: Group- A Conventional Sensed Mouth Wash

Study type

Interventional

Funder types

Other

Identifiers

NCT06790953

SOD/ERB/2024/36-200

Details and patient eligibility

About

Randomized Clinical trial to compare the reduction in dentin hypersensitivity after incorporating biogenically fabricated titania nanoparticles enriched Mouth Wash and Conventional Mouth Wash.Participants ranging between 20-50 years were allocated in two groups. Group A will use Conventional Mouth Wash without Nanoparticles. Group B will use titania nanoparticles enriched Mouth Wash. Both will use them for three months and then their VAS scoring will be checked.

Full description

In this study Novel biogenically fabricated titania nanoparticle reinforced Mouth Wash will be evaluated for dentine sensitivity . Participants following Inclusion criteria will be allocated in this study by Consecutive random sampling technique. Participants will be divided into two groups i.e Group-A and Group-B with dentin sensitivity of 30-80. Group A will be given Conventional Mouth Wash for three months and Group-B will be given titania nanoparticles enriched Mouth Wash for three months for the sensitivity. Sensitivity will be assessed using Visual analog scale (VAS) mean score after 1 month and then three months.

Enrollment

130 patients

Sex

All

Ages

20 to 50 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Participants ranging between 20-50 years, good general health but developed dentine sensitivity associated with tooth surface wear and loss during the past 6 months.
There was no history of allergy.
Participants did not use any mouth wash , dentifrice or medication in the last 3 months.
The involved teeth were viable, non-shaky, devoid of any decay, cracks and fillings.
There was an essential positive response to the provoking Air stimuli.
These teeth should display the visible signs of tooth loss and wear such as : attrition, abrasion, erosion and abfraction.

Exclusion criteria

Participants that might have developed allergy or used medications during the last 2 weeks or more.
The teeth having cracks, decay and fillings were also excluded. Patients who have undergone any periodontal surgery or gross periodontal issues.
Participants who used any desensitisizing toothpastes/mouthwashes and tooth bleaching agents within 2 months of the trial were also excluded positively.