Efficacy of Nutritional Therapy With High Methionine Content in the Treatment of NAFLD

Universidad Veracruzana

Status: Completed

Conditions: Non-alcoholic Fatty Liver Disease (NAFLD)

Treatments: Dietary Supplement: Experimental group (with diet)

Study type: Interventional

Funder types: Other

Identifiers

NCT04450875

001/060/0194 (Other Identifier)

ISP-CI-003/2014

Details and patient eligibility

About

To assess the effect of a methionine metabolism-based dietary strategy in patients with non-alcoholic fatty liver disease in order to reduce complications while improving the quality of life for patients.

Full description

A randomized controlled clinical trial with parallel design was performed, a ratio of at least one patient in the control group for each subject in the experimental group.

Enrollment: 121 patients

Sex: All

Ages: 20 to 99 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of Non-alcoholic Fatty Liver Disease by biochemical parameters used by the SteatoTest and Fatty Liver Index (IHG), greater than 60 points on the scale and confirmed by liver ultrasound

Exclusion criteria

• Previous diagnosis of cirrhosis, hepatocarcinoma, Wilson's disease, viral hepatitis B and C and neoplasms of any origin

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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121 participants in 2 patient groups

Experimental group (with diet)

Experimental group

Description:

It consisted in the administration of nutritional therapy with foods high in methionine according to the National Nutrient Database For Standard Reference (USDA) and adapted to the consumption and usual cost in the Mexican diet.

Treatment:

Dietary Supplement: Experimental group (with diet)

Control

No Intervention group

Description:

The control group continued with their usual diet for the same period of 3 months as the experimental group.