Efficacy of Olanzapine on Weight Gain in Advanced Gynecologic Cancer with Paclitaxel and Carboplatin: a Double Blind, Placebo-controlled Randomized Trial

Rajavithi Hospital

Status: Enrolling

Conditions: Weight Gain

Treatments: Other: weight gain each group

Study type: Interventional

Funder types: Other

Identifiers

NCT06288854

66222

Details and patient eligibility

About

• Efficacy of olanzapine on weight gain in advanced stage gynecologic cancer
• Proprotion of pateints in advanced stage gynecologic cancer who recieving paclitaxel and carboplatin chemotherapy gain weight on olanzapine or placebo

Full description

-Proprotion of pateints in advanced stage gynecologic cancer who recieving paclitaxel and carboplatin chemotherapy gain weight on olanzapine or placebo

Enrollment: 48 estimated patients

Sex: Female

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Advanced stage gynecologic cancer receiving Paclitaxel and carboplatin chemotherapy
• ECOG 0-1
• Normal CBC,Liver, renal function
• Communication in Thai language or Thai caregiver
• Inform consent

Exclusion criteria

• Pregnancy
• Active infection
• Bowel obstruction or history of bowel surgery
• On dopamine receptor antagonists or psychiatric or anticonvulsant medication
• Olanzapine allery
• Abnormal function of liver and renal
• Diabetic melitus or morbid obesity
• patient can't selfcare

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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48 participants in 2 patient groups, including a placebo group

Olanzapine

Experimental group

Description:

Olanzapine 5 mg oral OD

Treatment:

Other: weight gain each group

Placebo

Placebo Comparator group

Description:

Placebo

Treatment:

Other: weight gain each group