Efficacy of Oxytocin vs. Carbetocin in Prevention of Postpartum Hemorrhage After Cesarean Section

Shahid Beheshti University of Medical Sciences

Status and phase: Completed; Phase 2

Conditions: Postpartum Hemorrhage

Treatments: Drug: Oxytocin; Drug: Carbetocin

Study type: Interventional

Funder types: Other

Identifiers

NCT02079558

JANU2014TAHERIPANAH

IRHRC-021

Details and patient eligibility

About

Postpartum hemorrhage (PPH) is a common complication of childbirth and a leading cause of maternal morbidity and mortality. The prompt and effective treatment of subjects with PPH would reduce operation risks. Hence in this study, the efficacy of Oxytocin and Carbetocin was compared in prevention of postpartum hemorrhage after cesarean sections.

Enrollment: 220 patients

Sex: Female

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• At least one risk for postpartum hemorrhage and lack of hypersensitivity to oxytocin and carbetocin

Exclusion criteria

• Patients' refusal to cooperate, major therapeutic side effects, history of cardiac and renal disease or preeclampsia

Trial design

Primary purpose: Screening

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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220 participants in 2 patient groups

Oxytocin

Experimental group

Description:

A single 100 microgram IV dose of carbetocin after operation

Treatment:

Drug: Oxytocin

Carbetocin

Experimental group

Description:

A standard 30 international units (IU) IV infusion of oxytocin during two hours

Treatment:

Drug: Carbetocin