Efficacy of Plant-protein Diets in Patients With Chronic Kidney Disease

Osaka University

Status: Active, not recruiting

Conditions: Chronic Kidney Disease Stage 5

Treatments: Other: Plant-protein Diets; Other: Control Diets

Study type: Interventional

Funder types: Other

Identifiers

NCT05350098

21371

Details and patient eligibility

About

The purpose of this study is to evaluate the efficacy of plant-protein diets for 12 weeks in patients with advanced chronic kidney disease.

Enrollment: 40 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. patients with chronic kidney disease who were referred to the Outpatient Department of Nephrology at Osaka University Hospital
2. eGFR < 20 mL/min/1.73 m2
3. taking anigiotensin-converting enzyme inhibitors or angiotensin Ⅱ receptor blockers or angiotensin receptor neprilysin inhibitor
4. K < 5.5 mEq/L

Exclusion criteria

1. Being planned to intitate renal replacement therapies within 3 months
2. Having inflammatory bowel diseases
3. History of gastrointestinal tract surgery
4. Taking antibiotics within 1 month before the entry
5. Taking or being planned to start warfarin
6. Having dietary allergies
7. Having difficulty in oral intake
8. During pregnancy or breastfeeding
9. Unsuitable for participant in the trial by an attending physician

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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40 participants in 2 patient groups

A dietary intervention of plant-protein based diets

Experimental group

Treatment:

Other: Plant-protein Diets

A dietary intervention of control diets

Active Comparator group

Treatment:

Other: Control Diets