Efficacy of Platelet-rich Plasma in Treatment of Melasma

Instituto Mexicano del Seguro Social

Status and phase: Completed; Phase 2

Conditions: Melasma

Treatments: Biological: Platelet-Rich Plasma

Study type: Interventional

Funder types: Other

Identifiers

NCT03674203

R-2015-1301-88.

Details and patient eligibility

About

The application of Platelet Rich Plasma (PRP) on three occasions with an interval of 15 days between each one, is related to a decrease in the intensity of the spots and improvement in the quality of the skin of patients with melasma.

Full description

832/5000 Objective: To evaluate the effect of PRP for Melasma treatment. Material and methods: Prospective cohort with therapeutic intervention. Patients, female, with melasma were included. Changes in the melanin concentration of the face (MASI), degree of satisfaction (MELASQOL) and histological changes were clinically evaluated.

The Sp-MELASQOL questionnaire, Fitzpatrick and MASI scales were applied, and photographs were taken with ambient light and with Wood's light with the Janus-II General Model. The patients were evaluated and classified, before and after the treatment by means of dermatoscopy, which was performed using a dermatoscope with polarized light (DermLite DL3N®), which allows an increase from 6 to 400X.

The dermatoscopy reported the findings of: Quantity, Density and Depth of melasma.

Enrollment: 20 patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Previous diagnosis of melasma
• History of pregnancy with a time greater than 6 months
• Informed consent

Exclusion criteria

• In lactation period
• History of skin cancer
• History of liver, thyroid diseases
• With active acne lesions and traumatic lesions on the face
• PRP pre-treatmentPre-treatment for melasma with less than 6 months
• Hb values <10 g / dL or platelet count <105x109 / L

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

Application of platelet-rich plasma

Experimental group

Description:

The patients received three sessions of PRP application, at intervals of 15 days between each of them. It was applied by means of a 32G needle to introduce the PRP by means of superficial micro-injections via the mesotherapy technique (approximately 1.5-2.0 mm deep) and it was deposited in the papillary dermis of the rosotro.

Treatment:

Biological: Platelet-Rich Plasma