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Efficacy of Platelet Rich Plasma (PRP) on Mouth Opening and Pain After Surgical Extraction of Mandibular Third Molars.

F

Foundation University Islamabad

Status

Completed

Conditions

Tooth Extraction

Treatments

Procedure: Surgical Extraction
Procedure: Platelet Rich Plasma (PRP)

Study type

Interventional

Funder types

Other

Identifiers

NCT04452734
FUI/CTR/2020/3

Details and patient eligibility

About

Wisdom tooth extraction is the most common surgical procedure being carried out in oral surgical departments. The complications carried by post operative period include pain and trismus and may affect patient's quality of life.

PRP is an autologous concentrate of platelet in plasma and accelerate healing by production of growth factors. PRP is prepared from patient's own blood and later packed with gel sponge (Spongistone) in the experimental group immediately after surgical extraction of mandibular third molar teeth, followed by suture placement to close the surgical site.

Full description

Wisdom tooth extraction is the most common surgical procedure being carried out in oral surgical departments. The complications carried by post operative period includes pain, swelling, trismus , along with disturbance in post extraction wound healing which may significantly affect patient's quality of life.

PRP is an autologous concentrate of platelet suspended in plasma and accelerate healing by production of various growth factors. PRP is prepared from patient's own blood and later packed with gel sponge (Spongistone) in the experimental group immediately after surgical extraction of mandibular third molar teeth, followed by suture placement to close the surgical site. PRP speeds up healing by concentration of growth factors which can lessen the inflammation and decreases trismus and pain.

Enrollment

130 patients

Sex

All

Ages

18 to 45 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  1. Age between 18-45 iyears
  2. Either gender
  3. Patients requiring extraction of mandibular 3rd molars
  4. ASA grade1
  5. Nonsmokers & non alcoholics
  6. Not allergic to any medicines
  7. No pain before the extraction procedure
  8. No trismus, i.e. normal mouth opening before the extraction procedure -

Exclusion criteria

a) Systemic diseases b) Compromised immune system c) Platelet count less than 1.5 lacs/cmm d) Allergy to drugs e) Patients not willing to participate in the study f) Pregnant females/Lactating mothers g) Presence of pericoronitis, periapical infection or any associated lesion.

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

130 participants in 2 patient groups

Control Group
Active Comparator group
Treatment:
Procedure: Surgical Extraction
Study Group
Experimental group
Treatment:
Procedure: Surgical Extraction
Procedure: Platelet Rich Plasma (PRP)

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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