Efficacy of Pre- and Post-Operative Oral Dextromethorphan

Khon Kaen University

Status

Completed

Conditions

Efficacy of Dextromethorphan

Morphine Consumption

Pain

Treatments

Drug: pre-operatively followed by 30 mg three times per day after surgery

Study type

Interventional

Funder types

Other

Identifiers

NCT00199303

KhonKaen University

efficacy of dextromethorphan

Details and patient eligibility

About

We studied the effect of dextromethorphan (DEX), an N-methyl-d-aspartate antagonist, on analgesic consumption and pain scoring after abdominal hysterectomy. Our aim was to compare the analgesic effectiveness and incidence of adverse side effects of oral DEX with placebo (P)

Full description

One hundred patients were randomized to two groups. Group DEX was given 30 mg tablets of oral dextromethorphan with their pre-medication and three more times in the first 24 hours after surgery. Group P received the placebo following the same schedule. Post-operative analgesic requirements were assessed using a patient-controlled analgesia system.

Pain was assessed at rest using a visual analog scale in the post anesthetic care unit(PACU), 6 and 24 hours after surgery.

Sex

Female

Ages

30 to 60 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

women aged between 30 and 60, with an ASA physical status of I or II, undergoing elective total abdominal hysterectomy under general anesthesia.

Exclusion criteria

Women with a history of significant renal or hepatic impairment, allergy to any of the study medications, antitussive or NSAID use (48 hours or 1 week, respectively) before surgery, chronic pain and regular analgesic use, were excluded. Patients taking medications that could interact with dextromethorphan, including quinidine, flecainide, mexiletine, fluoxetine, amitriptyline, nortriptyline, and propafenone