Efficacy of Proton Pump Inhibitor for Chronic Cough Caused by Gastroesophageal Reflux; Double-blind, Placebo-controlled, Randomized Clinical Trial

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Yonsei University

Status

Completed

Conditions

Chronic Cough Caused by Gastroesophageal Reflux

Treatments

Drug: placebo
Drug: High-dose PPI
Drug: standard PPI

Study type

Interventional

Funder types

Other

Identifiers

NCT01888549
3-2011-0103

Details and patient eligibility

About

Efficacy of proton pump inhibitor for chronic cough caused by gastroesophageal reflux; double-blind, placebo-controlled, randomized clinical trial

Enrollment

48 patients

Sex

All

Ages

19 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

ages of 18 and 70 years had chronic cough of >8 weeks in duration

Exclusion criteria

1. abnormal chest X ray, PNS view 2. previous surgical or endoscopic antireflux procedure 3. previous aerodigestive malignancy or Barrett's oesophagus 4. current smokers or ex-smok-ers (defined as those who quit smoking <3 months prior to study enrolment or those who have quit, but have a 20 pack year smoking history) 5. Malignancy History (lung cancer, esophageal cancer etc.) 6. upper respiratory infection within 8 weeks of study enrolment 7. currently using a PPI, H2 blocker, beta-blocker, angiotensin-converting enzyme inhibitor, corticosteroid, methylxanthine, inhaled beta-agonist, anti-inflammatory agent or anticholinesterase drug at time of enrolment

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

48 participants in 3 patient groups, including a placebo group

arm1-High dose PPI
Experimental group
Treatment:
Drug: High-dose PPI
arm2-standard dose PPI
Active Comparator group
Treatment:
Drug: standard PPI
arm3-placebo
Placebo Comparator group
Description:
Esomeprazole placebo
Treatment:
Drug: placebo

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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