Efficacy of Proton Pump Inhibitors in Gastrointestinal Erosions and/or Ulcers

Shinshu University

Status and phase: Enrolling; Phase 2

Conditions: Gastrointestinal Erosions and/or Ulcers

Treatments: Drug: Oral Esomeprazol; Drug: Oral Bonoprazan

Study type: Interventional

Funder types: Other

Identifiers

NCT03315676

PPI 2017

Details and patient eligibility

About

The aim of this study is to collect the data of clinical efficacy and safety after the usage of bonoprazon and esomeprazole when the patients take NSAIDs more than 2 weeks and have gastrointestinal symptoms who have had gastrointestinal erosions and/or ulcers in the past.

Enrollment: 124 estimated patients

Sex: All

Ages: 20 to 99 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of NSAIDs-induced gastrointestinal Erosions and/or Ulcers who want to take Bonoprazan or Esomeprazole

Exclusion criteria

• Patients allergic to Bonoprazan or Esomeprazole

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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124 participants in 2 patient groups

Oral Bonoprazan

Active Comparator group

Description:

Daily intake of Bonoprazan

Treatment:

Drug: Oral Bonoprazan

Oral Esomeprazol

Active Comparator group

Description:

Daily intake of Esomeprazol

Treatment:

Drug: Oral Esomeprazol