Efficacy of Rectal Indomethacin in Prevention of Post-pancreatectomy Acute Pancreatitis

Shanghai Jiao Tong University School of Medicine

Status and phase: Not yet enrolling; Phase 2

Conditions: Pancreatectomy

Treatments: Other: Standard Medical Treatment; Drug: Indomethacin suppository

Study type: Interventional

Funder types: Other

Identifiers

NCT05722548

LYBWWG2023

Details and patient eligibility

About

The purpose of this study is to evaluate the efficacy of rectal indomethacin in prevention of post-pancreatectomy acute pancreatitis.

Full description

The purpose of this study is to evaluate the efficacy of rectal indomethacin in prevention of post-pancreatectomy acute pancreatitis.

Enrollment: 200 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

*All patients planned to undergo pancreatectomy.

Exclusion criteria

• asthma
• allergic reactions to NSAIDs
• CKD
• internal hemorrhoids
• anti-platelet medications

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

200 participants in 2 patient groups

Group A

Experimental group

Description:

Patients will be administered 100mg of Indomethacin Suppository sigle dose at the time of induction of anesthesia with Standard Medical Treatment

Treatment:

Other: Standard Medical Treatment

Drug: Indomethacin suppository

Group B

Active Comparator group

Description:

Standard Medical Treatment

Treatment:

Other: Standard Medical Treatment