Efficacy of Remifentanil in Preventing Emergence Agitation (agitation)

Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital

Status: Enrolling

Conditions: Emergence Agitation

Treatments: Drug: Remifentanil; Drug: Fentanyl; Drug: N2O

Study type: Interventional

Funder types: Other

Identifiers

NCT06539013

HTosunSONE

Details and patient eligibility

About

The primary aim of the study was to test the hypothesis that remifentanil administered for analgesia prevents emergence agitation more effectively than fentanyl and N2O in patients undergoing rhinoplasty who received desflurane as an inhaled anesthetic agent. The secondary aim of the study was to compare the demographic data, intraoperative and postoperative hemodynamic data, surgical time and modified Aldrete score of patients who received different intraoperative analgesia methods.

Enrollment: 99 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

The study included patients over the age of 18, planned to undergo rhinoplasty by the plastic and reconstructive surgery department, and American Society of Anesthesiologist (ASA) I-II.

Exclusion criteria

• Patients with a known history of allergy to the drugs to be administered in the study, ASA III and above, body mass index (BMI) 35>kg/m2, younger than 18 years of age, any problems that would prevent general anesthesia in the preoperative evaluation (upper respiratory tract infection, etc.), and those who did not agree to participate in the study were excluded from the study.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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99 participants in 3 patient groups

group 1 Remifentanily

Active Comparator group

Description:

Patients in Group 1 received 0.05-0.2 μg/kg/min IV remifentanil infusion as analgesic.

Treatment:

Drug: Remifentanil

group 2 N2O

Active Comparator group

Description:

N2O instead of 50% air was applied to patients in Group 2 for intraoperative analgesia.

Treatment:

Drug: N2O

group 3 Fentanly

Active Comparator group

Description:

In addition to Desflurane, 50% oxygen and 50% air, 1 μg/kg IV fentanyl bolus was administered as analgesic when there was a 20% increase in heart rate and blood pressure values during the operation for patients in Group 3.

Treatment:

Drug: Fentanyl