Efficacy of Retinal Nerve Fiber Layer (RNFL) / Retinal Thickness Ratio by Cirrus OCT Utilizing Spectral -Domain Technology as a Diagnostic Predictor of Glaucoma

Yonsei University

Status: Unknown

Conditions: Myopia; Glaucoma

Study type: Observational

Funder types: Other

Identifiers

NCT00772993

4-2008-0340

Details and patient eligibility

About

Glaucoma is presumed to be an axonal disease which starts at the lamina cribrosa. This assumption has led to the monitoring of the retinal nerve fiber layer thickness for the diagnosis and monitoring of progression of glaucoma. However, varying disc size, myopia and tilted discs affect the thickness of the retinal nerve fiber layer. This study aims to ascertain the ration of the retinal nerve fiber layer against full retina as a predictor of glaucoma diagnosis and progression.

Enrollment: 400 estimated patients

Sex: All

Ages: 10 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Primary open angle glaucoma
• Myopia
• Myopia with evidence of glaucoma
• Normal controls

Exclusion criteria

• Evidence of retinal disease
• BCVA < 0.4
• Secondary glaucoma due to intraocular inflammation
• Lens induced glaucoma
• Tumor induced glaucoma
• Neovascular glaucoma

Trial design

400 participants in 4 patient groups

1

Description:

Primary open angle glaucoma

2

Description:

Normal Control

3

Description:

Myopia with no evidence of glaucoma

4

Description:

Myopia with evidence og glaucoma