Efficacy of Riluzole in Surgical Treatment for Cervical Spondylotic Myelopathy (CSM-Protect)

AOSpine North America Research Network

Status and phase

Completed

Phase 3

Conditions

Cervical Spondylotic Myelopathy

Treatments

Drug: riluzole

Drug: Placebo medication

Study type

Interventional

Funder types

NETWORK

Identifiers

NCT01257828

SPN-10-001

Details and patient eligibility

About

CSM (Cervical spondylotic myelopathy) is the most common cause of spinal cord injury worldwide. While there is evidence from the recently completed SpineNet prospective study that surgical decompression is an effective treatment for CSM, it is clear that many patients have remaining neurological impairment. While surgery is relatively safe, approximately 3% of patients maintain a neurological problem. Given this background and data from preclinical models of non-traumatic and traumatic spinal cord injury, there is strong evidence to consider the potential benefit of adding a neuroprotective drug which aids in the treatment of patients with CSM whom are undergoing surgical decompression. Riluzole is FDA-approved for the treatment of amyotrophic lateral sclerosis, which has some similar clinical features to CSM. Riluzole is currently under investigation for traumatic spinal cord injury. Given this background, there is a strong basis to consider studying the potential neurological benefits of Riluzole as a treatment to surgical decompression in patients with CSM.

Enrollment

270 patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age between 18 and 80 years
Diagnosis of symptomatic cervical spondylotic myelopathy defined as a combination of:
1. one or more of the following symptoms:
  - Numb hands
  - Clumsy hands
  - Impairment of gait
  - Bilateral arm paresthesiae
  - l'Hermitte's phenomena
  - Weakness And,
2. one or more of the following signs:
  - Corticospinal distribution motor deficits
  - Atrophy of hand intrinsic muscles
  - Hyperreflexia
  - Positive Hoffman sign
  - Upgoing plantar responses
  - Lower limb spasticity
  - Broad based, unstable gait And,
3. MRI evidence of cervical spondylotic myelopathy
Scheduled for an elective surgery for cervical spondylotic myelopathy
Preoperative mJOA score ≥8 and ≤14
Women of child bearing potential must be:
- Postmenopausal defined as amenorrhea for at least 2 years.
- Surgically sterile, (have had a hysterectomy or bilateral oophorectomy, tubal ligation, or otherwise be incapable of pregnancy)
- Abstinent (at the discretion of the investigator)
- Having other congenital or medical condition that prevents subject from becoming pregnant
- If sexually active, be practicing an effective method of birth control such as hormonal prescription oral contraceptives, progesterone implants or injections, intrauterine device (IUD), or male partner with a vasectomy. A double-barrier method such as condoms, diaphragms or cervical caps with spermicidal foam, cream or gel may be used as a birth control method.
- Women of childbearing potential must have a negative serum β-human chorionic gonadotropin (β-hCG) pregnancy test or a negative urine pregnancy test at screening before the first dose of study drug is received.

Exclusion criteria

Previous surgery for CSM
Concomitant symptomatic lumbar stenosis
CSM symptoms due to cervical trauma (at the discretion of the investigator)
Hypersensitivity to riluzole or any of its components
Neutropenia measured as absolute neutrophil count (ANC) measured in cells per microliter of blood of < 1500 at screening visit
Creatinine level of > 1.2 milligrams (mg) per deciliter (dl) in males or > 1.1 milligrams per deciliter in females at screening visit Liver enzymes (ALT or AST) 3x higher than normal values at screening visit.
Liver enzymes (ALT or AST) 3x higher than normal values at screening visit.
Subject will be using any of the following medications which are classified as CYP1A2 inhibitors or inducers*during the course of the drug regimen:

Inhibitors:

Ciprofloxacin
Enoxacin
Fluvoxamine
Methoxsalen
Mexiletine
Oral contraceptives
Phenylpropanolamine
Thiabendazole
Zileuton

Inducers:

Montelukast
Phenytoin

*Note: no washout period required; if these medications are discontinued, subjects are eligible to be enrolled in the trial.
Systemic infection such as AIDS, HIV, and active hepatitis
Active malignancy defined as history of invasive malignancy, except if the patient has received treatment and displayed no clinical signs and symptoms for at least five years
Recent history (less than 3 years) of chemical substance dependency or significant psychosocial disturbance that may impact the outcome or study participation
Breastfeeding at screening visit and plan to continue during the course of the study drug
Unlikely to comply with the follow-up evaluation schedule
Unlikely to comply with investigational drug regime
Participation in a clinical trial of another investigational drug or device within the past 30 days
Is a prisoner
Unable to converse, read or write English at elementary school level