Efficacy of Serratus Anterior Plane Block With Dexmedetomidine During Breast Surgery

National Cancer Institute, Egypt

Status: Enrolling

Conditions: Analgesia

Treatments: Procedure: Single level serratus anterior plane block; Procedure: Bilevel serratus anterior plane block; Procedure: Bilevel serratus anterior plane block with dexmedetomidine; Procedure: Single level serratus anterior plane block with dexmedetomidine

Study type: Interventional

Funder types: Other

Identifiers

NCT05361837

AP2204-50104

Details and patient eligibility

About

This study aims to compare single level serratus block versus bilevel serratus block with and without dexmedetomidine in cancer patients undergoing modified radical mastectomy for breast cancer regarding pain control and possible side effects.

Enrollment: 172 estimated patients

Sex: Female

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients scheduled for modified radical mastectomy,
• Age 18-65 years,
• ASA I-II

Exclusion criteria

• patient refusal,
• coagulation defects,
• abnormal kidney or liver functions,
• local infection at site of injection.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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172 participants in 4 patient groups

Single level serratus anterior plane block

Active Comparator group

Description:

the allocated patients will receive single injection serratus anterior plane block at the level of third rib with local anesthetics only

Treatment:

Procedure: Single level serratus anterior plane block

Single level serratus anterior plane block with dexmedetomidine

Experimental group

Description:

the allocated patients will receive single injection serratus anterior plane block at the level of third rib with local anesthetics and dexmedetomidine

Treatment:

Procedure: Single level serratus anterior plane block with dexmedetomidine

Bilevel serratus anterior plane block

Experimental group

Description:

the allocated patients will receive injection serratus anterior plane block at 2 levels, the level of third rib and the level of the fifth rib with local anesthetics only

Treatment:

Procedure: Bilevel serratus anterior plane block

Bilevel serratus anterior plane block with dexmedetomidine

Experimental group

Description:

the allocated patients will receive injection serratus anterior plane block at 2 levels, the level of third rib and the level of the fifth rib with local anesthetics and dexmedetomidine

Treatment:

Procedure: Bilevel serratus anterior plane block with dexmedetomidine