Efficacy of SLN Block for Chronic Cough

Medical University of South Carolina (MUSC)

Status and phase

Completed

Phase 3

Conditions

Cough

Superior Laryngeal Nerve Block

Neurogenic Cough

Treatments

Procedure: Superior laryngeal nerve block

Procedure: Injection of steroid-lidocaine mixture

Procedure: Injection of placebo (saline)

Study type

Interventional

Funder types

Other

Identifiers

NCT04421092

00096384

Details and patient eligibility

About

This is a research study to find out if superior laryngeal nerve blocks are an effective way to reduce cough when compared to placebo (a substance without any medical value). Eligibility for the study include the following: age >18, cough history suggestive that the nerve to the voice box is overactive, non-smoker, Patients will be followed over time and assigned to either the treatment or placebo group at random. The treatment would be four superior laryngeal nerve blocks and the placebo would be four saline injections (the inactive substance). Study team will measure if the injection improved cough and ask patients to keep a log of symptoms and fill out questionnaires at each visit. After the four injections, patients will follow up in 3 months to see if cough has returned and if so, how severe the cough is.

Enrollment

17 patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

History consistent with neurogenic cough
Exclusion of other etiologies (see exclusion criteria)
Age ≥ 18

Exclusion criteria

Current neuromodulating medication use
Untreated other etiologies of cough:

Current smoker Current ACE/ARB use Abnormal PFTs within 6 months Uncontrolled OSA Abnormal CXR within 6 months RSI > 13 or RFS >11 AND workup positive for GERD (esophagram, 24-hour pH probe, manometry, EGD)