Efficacy of Split-dose of Oral MMS for Bowel Preparation in Elderly Patients

Air Force Military Medical University of People's Liberation Army

Status: Completed

Conditions: Bowel Preparation; Colonic Adenoma

Treatments: Other: split-dose of Magnesium Sulfate solution; Other: split-dose of PEG

Study type: Interventional

Funder types: Other

Identifiers

NCT04948567

KY20170119-2

Details and patient eligibility

About

Adequate bowel preparation is critical for successful colonoscopy and a large volume of PEG was required for bowel preparation in patients undergoing colonoscopy. The investigators conducted a a prospective, randomized, controlled study to compare low dose of oral magnesium sulfate solution with high dose PEG. The investigators found that patients who took low dose of oral magnesium sulfate solution had similar bowel preparation quality to patients who took PEG,but accompanied with fewer adverse events and better tolerance.

Enrollment: 1,174 patients

Sex: All

Ages: 60 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients who underwent colonoscopy

Exclusion criteria

• known or suspected bowel stricture or obstruction;
• history of colorectal surgery;
• significant gastroparesis or gastric outlet obstruction;
• toxic colitis or megacolon;
• severe acute inflammatory bowel disease;
• active gastrointestinal bleeding;
• suspected or confirmed chronic renal insufficiency and heart illness;
• disturbance of electrolytes ;
• unable to provide informed consent

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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1,174 participants in 2 patient groups, including a placebo group

split-dose of Magnesium Sulfate solution

Experimental group

Description:

Those assigned to MSS group were instructed to take 30ml of 50% magnesium sulfate solution and then drink 600ml water on the evening before colonoscopy. 70ml of 50% MMS and then 1500ml water was taken at least 4 hours before procedure on the colonoscopy day.

Treatment:

Other: split-dose of Magnesium Sulfate solution

split-dose of PEG

Placebo Comparator group

Description:

Patients in PEG group were instructed to take first dose of 1.5L PEG on the evening before colonoscopy and take the second dose of 1.5L PEG at least 4 hours before the colonoscopy procedure on the morning.

Treatment:

Other: split-dose of PEG