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Efficacy of Sr-89 for Differentiated Thyroid Cancer With Bone Metastases

Chinese Academy of Medical Sciences & Peking Union Medical College logo

Chinese Academy of Medical Sciences & Peking Union Medical College

Status and phase

Not yet enrolling
Phase 4

Conditions

Thyroid Neoplasm Follicular
Bone Metastases

Treatments

Drug: Sr-89

Study type

Interventional

Funder types

Other

Identifiers

NCT05466812
ZS-3477

Details and patient eligibility

About

Using sensitive markers (such as thyroglobulin, etc) to evaluate the efficacy of strontium-89 chloride (Sr-89) in differentiated thyroid cancer with bone metastases with an aim to breaking out of its palliation effect for bone pain.

Full description

Using biochemical markers (such as thyroglobulin), functional markers (such as change of tumor-background ratio on bone scan), etc to evaluate the efficacy of strontium-89 chloride (Sr-89) in differentiated thyroid cancer with bone metastases with an aim to breaking out of its palliation effect for bone pain.

Enrollment

20 estimated patients

Sex

All

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patients of differentiated thyroid cancer
  • Positive uptake by bone metastases on bone scan
  • Planing to have Sr-89 treatment

Exclusion criteria

  • Having received treatment for bone metastases within one month of the study (such as radiotherapy, surgery, targeted therapy, chemotherapy, etc., among which denosumab and bisphosphate were allowed as basic treatment)
  • Having received radioactive iodine therapy within half a year before the study
  • There are bone related events, such as fracture, spinal cord compression, etc.

Trial design

Primary purpose

Treatment

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

20 participants in 1 patient group

Sr-89 treated group
Experimental group
Description:
Sr-89 treatment
Treatment:
Drug: Sr-89

Trial contacts and locations

1

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Central trial contact

Yan-Song Lin; Xian-Feng Cao

Data sourced from clinicaltrials.gov

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