Efficacy of Therapy With the Spironolactone Pills Compared to Minoxidil Lotion in Female Pattern Hair Loss

University of British Columbia

Status and phase: Completed; Phase 2

Conditions: Female Pattern Hair Loss

Treatments: Drug: Spironolactone; Drug: Minoxidil

Study type: Interventional

Funder types: Other

Identifiers

NCT00175617

C05-0060

Details and patient eligibility

About

This study evaluates the efficacy of therapy with the anti-androgen spironolactone compared to topical minoxidil in female pattern hair loss.

Enrollment: 40 estimated patients

Sex: Female

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Subjects must be premenopausal women older than 18 with female pattern hair loss.

Exclusion criteria

• Androgen excess
• Other scalp or hair disorders
• Contraindications to spironolactone treatment, especially pregnancy, electrolyte imbalances, history of breast cancer, or intake of interfering drugs
• Contraindications to minoxidil treatment, especially patients who are allergic to this treatment or have a history of low blood pressure or irregular heart beats

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)