Efficacy of Three Antiemetics in Preventing Nausea and Vomiting

Chongqing Medical University

Status and phase: Completed; Phase 4

Conditions: Nausea and Vomiting

Treatments: Drug: tropisetron; Drug: metoclopramide; Drug: dexamethasone; Other: normal saline

Study type: Interventional

Funder types: Other

Identifiers

NCT05533281

Nausea and vomiting

Details and patient eligibility

About

To explore the effect of commonly used antiemetic drugs on reducing nausea and vomiting caused by intravenous tramadol injection, so as to reduce the incidence of nausea and vomiting in clinical use of tramadol and provide guidance for the clinical use of tramadol injection

Enrollment: 200 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists classification I-II
• 18.5≤BMI≤28
• Patients who receiving breast and thyroid surgery and requiring general anesthesia and receive PCIA
• Voluntarily and be able to understand and sign the informed consent form

Exclusion criteria

• Long-term use of analgesics, psychotropic drugs (including opioids, NSAIDS, antidepressants) history
• History of allergy to opioids
• Patients with a history or family history of epilepsy that has not been controlled by treatment
• Sedatives and antidepressants were used 24 hours before surgery
• Failure to cooperate with the study for any reason or in the opinion of the investigator

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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200 participants in 4 patient groups, including a placebo group

tropisetron

Experimental group

Description:

Troisetron was given 30 minutes in advance, and then tramadol 1.5mg/kg was intravenously injected with a micropump at a constant speed.

Treatment:

Drug: tropisetron

metoclopramide

Experimental group

Description:

Metoclopramide was given 30 minutes in advance, and then tramadol 1.5mg/kg was injected intravenously with a micropump at a constant speed.

Treatment:

Drug: metoclopramide

dexamethasone

Experimental group

Description:

Dexamethasone was given 30 minutes in advance, and then tramadol 1.5mg/kg was injected intravenously with a micropump at a constant speed.

Treatment:

Drug: dexamethasone

normal saline

Placebo Comparator group

Description:

Equal dose of normal saline was given 30 minutes in advance, and then tramadol 1.5mg/kg was given intravenously to ensure constant speed.

Treatment:

Other: normal saline