Efficacy of Topical 0.2% Xanthan Gum in Patients With Dry Eye

SIFI

Status: Completed

Conditions: Dry Eye

Treatments: Device: carboxymethylcellulose; Device: xanthan gum

Study type: Interventional

Funder types: Industry

Identifiers

NCT01959854

XNTME2013

Details and patient eligibility

About

The purpose of this study is to evaluate the effect of an ophthalmic solution containing 0.2% xanthan gum in reducing symptoms and signs of dry eye as well as tear film markers of oxidative stress.

Full description

Oxidative stress is the result of an imbalance between the production of reactive oxygen species (ROS) and antioxidant systems . The eye is constantly exposed to solar UV radiation which is the major inducer of ROS production and therefore oxidative stress has been implicated in the pathogenesis of several eye disease, including dry eye. Xanthan gum is a complex exopolysaccharide utilized as a food additive. Its chemical structure shows a capacity to react with ROS indicating a role as an anti-oxidative molecule.

In the present study aging patients with dry eye will be enrolled. Signs and symptoms of dry eye as well as levels of oxidative stress in tear will be evaluated afte 30 days of treatment with eye drops containing carboxymethylcellulose or xanthan gum.

Enrollment: 30 patients

Sex: All

Ages: 60+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Ocular Surface Disease Index > 12<23 and age >59 yrs

Exclusion criteria

• contact lens wear and use of other ophthalmic solutions with the exception of artificial tears

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

30 participants in 2 patient groups

carboxymethylcellulose

Active Comparator group

Description:

1 drop in each eye four times a day for 30 days

Treatment:

Device: carboxymethylcellulose

xanthan gum

Experimental group

Description:

1 drop in each eye four times a day for 30 days

Treatment:

Device: xanthan gum