Efficacy of Topical Cysteamine in Nephropathic Cyctinosis

The Eye Center and The Eye Foundation for Research in Ophthalmology

Status: Completed

Conditions: Corneal Cystine Crystals; Nephropathic Cyctinosis

Treatments: Drug: Cysteamine

Study type: Interventional

Funder types: Other

Identifiers

NCT02766855

TEC C123

Details and patient eligibility

About

The aim of this study is to evaluate the efficacy of topical cysteamine eye drops in the treatment of corneal cystine crystals deposits in patients with nephropathic cystinosis.

Full description

A total of 26 patients with nephropathic cystinosis were included in this prospective study. Patients were evaluated for improvement of corneal cysteine deposits crystals and photophobia following treatment with topical 0.55% cysteamine eye drops.

Enrollment: 26 patients

Sex: All

Ages: 8 months to 19 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with confirmed diagnosis of nephropathic cystinosis
• leucocyte cystine concentration level of more than 2.0 nmol half-cystine/ mg protein
• clinical evidence of tissue deposition of cystine and tissue damage due to cystinosis

Exclusion criteria

• Allergy to cysteamine

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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26 participants in 1 patient group

cysteamine eye drops

Experimental group

Description:

Patients used cysteamine eye drops every 2 hours while awake to both eyes.

Treatment:

Drug: Cysteamine