Efficacy of Tranexamic Acid in Preventing Post Operative Blood Loss in Bone Sarcoma Patient

Shaukat Khanum Memorial Cancer Hospital & Research Centre

Status and phase: Enrolling; Early Phase 1

Conditions: Blood Loss, Surgical

Treatments: Other: normal saline; Drug: Tranexamic acid injection

Study type: Interventional

Funder types: Other

Identifiers

NCT05427513

IRB-22-07

Details and patient eligibility

About

investigator will see the efficacy of tranexamic acid in limb salvage surgery patients which will prevent blood loss and help in conservation of blood products.

Enrollment: 42 estimated patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Limb sarcoma of upper and lower limb
• Limb salvage

Exclusion criteria

• liver insufficiency
• renal insufficiency
• allergic to drug
• history of thromboembolic condition
• pregnancy
• metastatic disease

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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42 participants in 2 patient groups, including a placebo group

placebo

Placebo Comparator group

Description:

will injection 10 ml of normal saline to ensure binding

Treatment:

Other: normal saline

tranexamic acid(TXA)

Active Comparator group

Description:

will inject tranexamic acid according to body weight

Treatment:

Drug: Tranexamic acid injection