Efficacy of Tranexamic Acid on Blood Loss During Percutaneous Nephrolithotomy.

Kafrelsheikh University

Status: Unknown

Conditions: Renal Stones; Nephrolithiasis

Treatments: Drug: Tranexamic acid injection

Study type: Interventional

Funder types: Other

Identifiers

NCT04367155

RS/19.22

Details and patient eligibility

About

Efficacy of tranexamic acid on blood loss during percutaneous nephrolithotomy. a double-blind, placebo-controlled randomized clinical trial.

Full description

To evaluate whether intravenous tranexamic acid or tranexamic acid in the irrigation fluid in percutaneous nephrolithotomy (PCNL) in reducing bleeding during and after PCNL.

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patient 18 years or older
• Stones ≥ 2 cm and/or mild to moderate hydronephrosis.

Exclusion criteria

• Age <18 years or Pregnancy
• Bilateral simultaneous PCNL
• Morbid obesity (BMI >40)
• Refuse to complete study requirements
• Untreated UTI
• Atypical bowel interposition by CT
• Tumour in the presumptive access tract area or Potential malignant kidney tumour

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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200 participants in 2 patient groups

tranexamic acid local

Active Comparator group

Description:

tranexamic acid inside the irrigation fluid

Treatment:

Drug: Tranexamic acid injection

tranexamic acid IV

Active Comparator group

Description:

tranexamic acid injection

Treatment:

Drug: Tranexamic acid injection