Efficacy of Twice Weekly Hemodialysis in Patients With Residual Kidney Function

Palo Alto Veterans Institute for Research

Status: Completed

Conditions: Hemodialysis; Kidney Failure, Chronic

Treatments: Other: Twice Weekly Hemodialysis then Thrice Weekly Hemodialysis; Other: Thrice Weekly Hemodialysis then Twice Weekly Hemodialysis

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT03874117

SIT0003AGG

R01DK118426 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The study will determine the efficacy of twice weekly hemodialysis in patients with residual kidney function.

Full description

Hemodialysis patients who have residual kidney function will undergo two 4-week study (twice weekly versus thrice weekly hemodialysis) using a cross-over design. Blood, urine, and dialysate samples will be collected at the end of each study period to determine adequacy of treatment and to assess uremic solute levels. Participants will complete quality of life questionnaires and cognitive paper tests.

Enrollment: 58 patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients on hemodialysis who have residual kidney function with residual urea clearance (Kru) >2.5 mL/min.
• been on hemodialysis for at least 3 months.
• adherence to regular dialysis treatments.

Exclusion criteria

• inability to achieve adequate hemodialysis.
• planned revision of hemodialysis vascular access.
• hospitalized within the past 2 months.

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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58 participants in 2 patient groups

Twice Weekly Hemodialysis then Thrice Weekly Hemodialysis

Other group

Description:

Twice weekly hemodialysis for 4 weeks, then thrice weekly hemodialysis for 4 weeks.

Treatment:

Other: Twice Weekly Hemodialysis then Thrice Weekly Hemodialysis

Thrice Weekly Hemodialysis then Twice Weekly Hemodialysis

Other group

Description:

Thrice weekly hemodialysis for 4 weeks, then twice weekly hemodialysis for 4 weeks.

Treatment:

Other: Thrice Weekly Hemodialysis then Twice Weekly Hemodialysis