Efficacy of Two Intermittent Subglottic Secretion

Jilin University

Status: Unknown

Conditions: Ventilator Associated Pneumonia

Treatments: Procedure: Subglottic secretion lavage combined with aspiration; Procedure: Subglottic secretion aspiration

Study type: Interventional

Funder types: Other

Identifiers

NCT03871985

SSD-SSLACA

Details and patient eligibility

About

The purpose of this study is to determine the efficacy of intermittent subglottic secretion lavage combined with aspiration preventing ventilator associated pneumonia in patients with severe neurological disease

Full description

Ventilator-associated pneumonia (VAP) is a common and serious complication of mechanical ventilation. Many studies have shown that the accumulation of subglottic secretions above the endotracheal cuff plays an important role in the pathogenesis of VAP. Subglottic secretion drainage (SSD) has been shown to be associated with a lower incidence of VAP in previous meta-analyses. Most studies in past reported that in the group of patients in whom endotracheal tube (ETT) was used and subglottic secretion drainage was applied compared to the group without subglottic secretion drainage.Very few studies compared two different methods of SSD,such as subglottic secretion lavage combined with aspiration or pure aspiration.The tubes need frequent cleaning as they often get blocked, especially the draining duct. This may be the reason why they are not commonly applied. However,subglottic secretion lavage combined with aspiration can reduce the incidence of tube blockage.So The purpose of this study is to determine the efficacy of intermittent subglottic secretion lavage combined with aspiration preventing ventilator associated pneumonia in patients with severe neurological disease.

Enrollment: 234 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients aged between 18 and 80 years requiring mechanical ventilation for more than 72 hours with placement of an ETT( equipped with a dorsal suction catheter for subglottic secretion drainage)

Exclusion criteria

• Exclusion criteria were patients endotracheal intubation was performed before admission, history of HIV, immunosuppression, leukopenia, patient refusal,and

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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234 participants in 2 patient groups

Lavage combined with aspiration

Experimental group

Description:

Intermittent subglottic secretions lavage combined with aspiration

Treatment:

Procedure: Subglottic secretion lavage combined with aspiration

Pure aspiration

Active Comparator group

Description:

Intermittent subglottic secretions aspiration

Treatment:

Procedure: Subglottic secretion aspiration