Efficacy of Two Onabotulinum Toxin Doses

Swiss Paraplegic Research, Nottwil

Status: Completed

Conditions: Overactive Detrusor; Neurogenic Bladder

Treatments: Drug: Injection of Onabotulinum toxin

Study type: Observational

Funder types: NETWORK

Identifiers

NCT03388086

2017-17

Details and patient eligibility

About

The changes in bladder function after the injection of Onabotulinum toxin into the detrusor in individuals with neurogenic bladder overactivity will be investigated retrospectively. The records of all patients treated with Onabotulinum toxin injections into the detrusor since 2000 will be evaluated. The changes in the urodynamic values after the injection of 300 units of Onabotulinum toxin will be compared with the changes after the injection of 200 units. Furthermore, the differences in urinary continence, duration between injections, side effects and complications between the two groups will be investigated.

Enrollment: 56 patients

Sex: All

Ages: 18 to 99 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• neurogenic detrusor overactivity
• spinal cord injury
• Onabotulinum toxin injections into the detrusor from 2000-2017

Exclusion criteria

• missing urodynamic values before or after Onabotulinum toxin injections

Trial design

56 participants in 2 patient groups

Onabotulinum 300 units

Treatment:

Drug: Injection of Onabotulinum toxin

Onabotulinum 200 units

Treatment:

Drug: Injection of Onabotulinum toxin