Efficacy of Urokinase Containing Locking Solutions for Thrombotic Dysfunction of Tunneled Hemodialysis Catheters

Universitair Ziekenhuis Brussel

Status: Completed

Conditions: Vascular Access Devices; Kidney Failure, Chronic

Treatments: Device: Urokinase locking solution

Study type: Observational

Funder types: Other

Identifiers

NCT02770560

1

Details and patient eligibility

About

Thrombotic dysfunction is a common complication of tunneled cuffed catheters (TCC) leading to inadequate dialysis dose, need to catheter replacement with as consequence progressive exclusion of vascular sites. Thrombolytic agent can be used as therapeutic locking solution to dissolve the clotting formed in of around the catheter lumen. There are few studies on the optimal approach of TCC-related thrombosis with thrombolytic containing locking solution (dose, number of administrations, timing of administration - intra or interdialytic use). The primary objective of this retrospective study was to compare the efficacy of inter versus intradialytic Urokinase containing locking solution on restoration of the TCC blood flow. The investigators also assess the question of multiple administrations of Urokinase are more efficient than one single administration

Enrollment: 148 patients

Sex: All

Ages: 18 to 99 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Hemodialysis patients over 18 years old, receiving hemodialysis between 1st May 2010 and 31st October 2014 via a tunneled cuffed catheter at the Hemodialysis Unit of Universitair Ziekenhuis Brussel Hospital.

Exclusion criteria

• Patients younger than 18 years old
• Patients with a temporary dialysis catheter
• Patients who never received a tunneled hemodialysis catheter in this period
• Patients who didn't have a medical file at the Universitair Ziekenhuis Brussel Hospital

Trial design

148 participants in 1 patient group

Chronic hemodialysis patients with a tunneled cuffed catheter

Description:

In case of thrombotic dysfunction of the dialysis catheter : administration of Urokinase (100 000 units in total) as locking solution in the dead space of the catheter lumen, interdialytic (between two dialysis sessions) or intradialytic (during the dialysis in case of complete obstruction of the dialysis catheter)

Treatment:

Device: Urokinase locking solution