Efficacy of Viscosupplementation Associated With Intra-articular Corticosteroid Injection Versus Intra-articular Injection of Corticosteroids Alone in Osteoarthritis of Hip (VISCOSUPP-HIP)

CHU de Reims

Status and phase

Completed

Phase 3

Conditions

Hip Osteoarthritis

Treatments

Device: control group

Device: Experimental group

Study type

Interventional

Funder types

Other

Identifiers

NCT02862639

PA12069

Details and patient eligibility

About

The current management of osteoarthritis is based on non-pharmacological and pharmacological means which include intra-articular injections.

The recommendations on the management of hip osteoarthritis stipulate that intra-articular injections of corticosteroid may be considered in patients with an exacerbation not responding to oral treatments. Several recent studies show the effectiveness of intra-articular corticosteroids compared with anesthetics. The intra-articular injection of viscosupplementation alone has never been validated in this indication since controlled studies did not show efficacy over placebo. At present, viscosupplementation is considered an anti-osteoarthritic symptomatic slow-acting and its interest is not yet established in hip osteoarthritis.

Full description

Show the superiority of intra-articular injection of viscosupplementation in combination with corticosteroid compared to intra-articular injection of corticosteroid alone in the treatment of hip osteoarthritis.

Enrollment

43 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

patients with hip osteoarthrosis (stage II et III according Kellgren et Lawrence)
walking alone patients
patient consenting to participate to the study
patient enrolled in the national healthcare insurance program
patient older than 18 years

Exclusion criteria

Patients with hip osteoarthrosis (stage I et IV according Kellgren et Lawrence)
patients with rapidly destructive hip osteoarthritis
patients with inflammatory rheumatism
patients with microcrystalline arthritis
patients with hip osteonecrosis
patients who received corticosteroids during the previous three months
patients who received a intra articular injection of viscosupplementation during the previous six months
patient with haemostatic disorder
patient with consumption of painkillers tier 3