Efficacy of Vitamin C Administration for the Prevention of Postpolypectomy Bleeding

Ilam University of Medical Sciences

Status: Completed

Conditions: Postpolypectomy Bleeding

Treatments: Other: Normal Saline; Other: Ascorbic acid

Study type: Interventional

Funder types: Other

Identifiers

NCT03400020

13961019

Details and patient eligibility

About

Postpolypectomy bleeding is the most common major complication following a colonoscopic polypectomy procedure. The incidence rate ranging from 0.3 to 6.1%. Several preventive methods such as detachable snare and adrenaline injection have been proposed in the management of postpolypectomy bleeding in large colonic polyps. It has been demonstrated that administration of ascorbic acid (vitamin C) in abdominal surgeries could reduce the blood loss during the procedure, operation time and days of hospitalization. So the investigators designed a prospective, randomized study to compares the efficacy of vitamin C administration with application of prophylactic clip and detachable snare in the prevention of postpolypectomy bleeding in large polyps.

Full description

In this prospective, randomized clinical trial, patients diagnosed with colon polyps with a diameter > 10 mm will randomized to receive either a 500 mg vitamin C in normal saline injection or a normal saline injection 2 hours before polypectomy. This administration will continued for 3 days after polypectomoy. Postpolypectomy bleeding is defined either as (1) early: occurring either during an endoscopic procedure or immediately after as hematochezia within 24 h or (2) delayed: any bleeding event that occurring between day 2 and day 30 following the polypectomy procedure.

Enrollment: 156 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Colorectal polyps larger than 10 mm.

Exclusion criteria

bleeding tendency poor preparation

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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156 participants in 2 patient groups, including a placebo group

Ascorbic acid

Experimental group

Description:

Ascorbic acid 1000 mg in normal saline IV 2 hours before the operation and thereafter 500 mg in normal saline IV daily for three days.

Treatment:

Other: Ascorbic acid

Normal saline

Placebo Comparator group

Description:

Normal saline IV infusion 2 hours before the operation and for three days after operation.

Treatment:

Other: Normal Saline