Efficacy of Vitamin C Injection on Fatigue in Workers After Work

DongGuk University

Status and phase: Completed; Phase 3; Phase 2

Conditions: Fatigue

Treatments: Dietary Supplement: Normal saline; Dietary Supplement: Ascorbic acid (Vitamin C)

Study type: Interventional

Funder types: Other

Identifiers

NCT00633581

DUIH 2008-1-1

Details and patient eligibility

About

Fatigue is one of the most frequently observed symptoms for company workers, and oxidative stress is regarded as one of its cause. Vitamin C is a well-known antioxidant, and the investigators seek for evidence of the efficacy of high dose vitamin C parenteral supplement on fatigue symptoms of company workers after work.

Full description

Previous studies dealing with vitamin C were focusing on terminal cancer patients or those with chronic fatigue syndrome. Since used drug dosage and the ways of administering vitamin C were not identical, the results were not consistent throughout those studies. This study is aimed to evaluate the efficacy of high dose vitamin C with parenteral supplement on relieving fatigue for apparently healthy volunteers.

Enrollment: 150 patients

Sex: All

Ages: 20 to 49 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Company workers working at least 5 days a week from morning to evening
• Volunteers who provided written informed consent

Exclusion criteria

• Acute illness
• Chronic disease such as diabetes, hypertension, liver disease, or renal disease
• Previous history of renal stone or gout
• Pregnant or lactating women
• Hypersensitivity to vitamins or intravenous injections
• History of vitamin supplements orally or parenterally within 2 days

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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150 participants in 2 patient groups, including a placebo group

1

Experimental group

Description:

Intravenous injections of 10 grams(20ml as a solution) of vitamin C with 100ml of normal saline over 30 minutes.

Treatment:

Dietary Supplement: Ascorbic acid (Vitamin C)

2

Placebo Comparator group

Description:

Intravenous injections of 120ml of normal saline over 30 minutes.

Treatment:

Dietary Supplement: Normal saline