Efficacy of Vitamin E in Preventing Contrast-Induced Acute Kidney Injury Following Coronary Angiography

Urmia University of Medical Sciences

Status and phase: Completed; Phase 3

Conditions: Unstable Angina; Stable Angina; Post MI; Non ST Segment Elevation Myocardial Infarction

Treatments: Drug: Vitamin E

Study type: Interventional

Funder types: Other

Identifiers

NCT02070679

UMSU-Cardiology-1

Details and patient eligibility

About

The purpose of this study is to evaluate the effect of vitamin E on preventing from incidence of contrast induced acute kidney injury (CI-AKI) in the patients who undergone coronary angiography.

Enrollment: 284 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. All patients whon have either stable coronary artery disease (CAD) or recent acute coronary disease (ACS) and are scheduled for coronary angiography.
2. Patients who have eGFR ≤60 ml/min/1.73 m2

Exclusion criteria

1. Allergy to contrast media
2. Cardiogenic shock
3. Pulmonary edema
4. Overt cardiac failure or left ventricular ejection fraction ≤ 30%
5. Acute kidney injury
6. The history of receiving contrast media for any medical diagnostic or therapeutic procedures during previous 5 days
7. The history of dialysis
8. Being pregnant
9. Having recent acute myocardial infarction
10. Taking antioxidants and nephrotoxic drugs including NSAID and ACE-I on previous 2 days

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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284 participants in 2 patient groups, including a placebo group

Placebo

Placebo Comparator group

Vit-E

Active Comparator group

Description:

600 IU on 12 hours before angiography and 400 IU on 2 hours before angiography

Treatment:

Drug: Vitamin E