Efficacy of Vonoprazan Based Dual and Triple Therapy for Patient With Helicobacter Pylori Infection

Sohag University

Status: Enrolling

Conditions: H. Pylori Infection

Treatments: Drug: Efficacy of Vonoprazan based triple therapy for naive patient with Helicobacter Pylori infection; Drug: Efficacy of PPI based triple therapy for naive patient with Helicobacter Pylori infection; Drug: Efficacy of Vonoprazan based dual therapy for naive patient with Helicobacter Pylori infection

Study type: Interventional

Funder types: Other

Identifiers

NCT07045688

Soh-Med--25-5-10MS

Details and patient eligibility

About

This study aims to assess Efficacy of vonoprazan based dual and triple therapy for naïve patient with Helicopacter Pylori infection in Sohag Government .

Enrollment: 150 estimated patients

Sex: All

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age: >18 years old.
• H. pylori infection: Confirmed by histopathology or non-invasive tests (e.g., stool antigen test).

Exclusion criteria

• Prior H. pylori treatment: Previous treatment for H. pylori infection.
• Allergies: Known allergies to study medications or components.
• Patients cannot finish treatment course.
• Patient missed follow up.
• Patients refusing or neglecting test of cure for H. pylori.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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150 participants in 3 patient groups

Efficacy of Vonoprazan based dual therapy for naive patient with Helicobacter Pylori infection

Active Comparator group

Description:

we assess the efficacy of Vonoprazan based dual therapy for eradication of Helicobacter Pylori infection in naive patient.

Treatment:

Drug: Efficacy of Vonoprazan based dual therapy for naive patient with Helicobacter Pylori infection

Efficacy of Vonoprazan based triple therapy for naive patient with Helicobacter Pylori infection

Active Comparator group

Description:

we assess the efficacy of Vonoprazan based triple therapy for eradication of Helicobacter Pylori infection in naive patient.

Treatment:

Drug: Efficacy of Vonoprazan based triple therapy for naive patient with Helicobacter Pylori infection

Efficacy of PPI based triple therapy for naive patient with Helicobacter Pylori infection

Active Comparator group

Description:

we assess the efficacy of proton pump inhibitors (PPI) based dual therapy for eradication of Helicobacter Pylori infection in naive patient.

Treatment:

Drug: Efficacy of PPI based triple therapy for naive patient with Helicobacter Pylori infection