Efficacy Parecoxib and Ketorolac as Preemptive Analgesia in Spine Fusion

Prince of Songkla University

Status and phase: Completed; Phase 4

Conditions: Postoperative Pain

Treatments: Drug: Ketorolac; Drug: Parecoxib

Study type: Interventional

Funder types: Other

Identifiers

NCT01859585

PSU-0001

Details and patient eligibility

About

The purpose of this study is to evaluate the efficacy of Parecoxib and Ketorolac as a preemptive analgesia in patients undergoing lumbar spinal fusion.

Full description

A prospective, double-blinded randomized control trial. Randomly allocated patient undergoing posterior lumbar spinal fusion into 3 groups (n=32) to receive Parecoxib, Ketorolac and Placebo around 30 minutes prior to incised skin. Efficacy was assessed by visual analog scale score (0-10), total opioid consumption, complication and bleeding also recorded.

Enrollment: 96 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing lumbar spinal fusion for one to three levels
• ASA class I or II

Exclusion criteria

• History of allergy to Sulfa group
• History of allergy to OPOID or NSAIDs
• Contraindicate to NSAIDs use
• History of coagulopathy or platelet disfunction

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

---

96 participants in 3 patient groups

Parecoxib

Experimental group

Description:

Parecoxib

Treatment:

Drug: Parecoxib

Ketorolac

Experimental group

Description:

Ketorolac

Treatment:

Drug: Ketorolac

No medication

No Intervention group

Description:

No medication