Efficacy & Safety of 980nm Diode Laser vs. Cryotherapy for Plantar Warts (LAVsCryWarts)

F

Fundación Universidad Católica de Valencia San Vicente Mártir

Status

Completed

Conditions

Warts of Foot

Treatments

Other: 980nm diode laser applied
Other: Liquid nitrogen sprayed

Study type

Interventional

Funder types

Other

Identifiers

NCT06228521
UCV/2022-2023/080

Details and patient eligibility

About

The goal of this clinical trial is to compare and test the efficacy of two treatments for plantar warts. The main questions it aims to answer are: Which treatment has a higher cure rate for eliminating plantar warts? Which treatment causes less pain during the procedure? Participants with plantar warts will: Be randomly assigned to receive either cryotherapy or laser therapy Undergo 4 treatment sessions at weekly intervals Have their warts assessed for complete clearance after treatment Rate their pain levels during each session Researchers will compare the cryotherapy and laser therapy groups to see if there are differences in: Rates of complete wart clearance Pain levels reported during treatment Adverse effects

Full description

Background: Plantar warts are a common dermatological condition caused by human papillomavirus infection. They can be painful and negatively impact quality of life. Many treatments exist but there is lack of consensus on the optimal approach. Objectives: Primary objective: To compare the efficacy of 980nm diode laser versus liquid nitrogen cryotherapy for clearing plantar warts, as measured by the complete clearance rate at 4 weeks post-treatment. Secondary objectives: To evaluate and compare pain levels during treatment procedures and adverse events between both groups. Study design: Randomized, double-blind clinical trial. Participants: 32 patients aged 18-65 years old with 1-3 plantar warts located on weight-bearing areas of the foot. Interventions: Laser group: 980nm diode laser applied to each wart for 5 seconds at 2W power and 1mm spot size. 4 sessions at weekly intervals. Cryotherapy group: Liquid nitrogen sprayed on each wart using a standardised technique. Freeze-thaw cycle repeated up to 3 times per wart per session. 4 sessions at weekly intervals. Main outcomes: Complete clearance rate of plantar warts at 4 weeks treatment session. Assessed by physical examination. Pain during procedure measured with Visual Analogue Scale (VAS). Adverse events monitored during follow-up. Randomization and blinding: Subjects will be randomly allocated to each group with a 1:1 ratio. Investigators assessing outcomes will be blinded to group assignment. Analysis: Intention-to-treat analysis will be performed. Chi-squared test will compare clearance rates. T-test will compare pain scores.

Enrollment

44 patients

Sex

All

Ages

18 to 60 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patients with recalcitrant, mosaic and simple HPV

Exclusion criteria

  • Diabetic, ischaemic and immunosuppressed patients
  • Patients with cold intolerance
  • Patients with any of the following conditions (blood dyscrasias of unknown origin, cryoglobulinaemia, cryofibrinogenemia, collagen or autoimmune disease)
  • Patients who do not sign the informed consent form.

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

44 participants in 2 patient groups

Laser Group
Experimental group
Description:
LASEmaR MINI 980 nm
Treatment:
Other: 980nm diode laser applied
Cryotherapy group:
Active Comparator group
Description:
CryoIQ
Treatment:
Other: Liquid nitrogen sprayed

Trial contacts and locations

2

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Central trial contact

Raul Gallego-Estevez; Giuliana Secolo

Data sourced from clinicaltrials.gov

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