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Severe forms of scabies (crusted scabies and profuse scabies) require a specific treatment. Ivermectin is a recommended treatment in common forms of scabies and represents a promising treatment in crusted scabies in case reports. However, response to ivermectin remains variable among studies, and there is no consensus on the schemes to adopt (dosages and administrations). Ivermectin at 400 µg/kg has already been used, without showing toxicity (in head lice treatment in particular). Investigators propose to demonstrate that 400µg/kg ivermectin dosage will show better efficacy than a 200µg/kg in patients with severe forms of scabies (crusted and profuse).
Enrollment
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Inclusion criteria
Patients ≥ 18 years old, diagnosed with severe forms of scabies
clinical criteria : cutaneous lesions of scabies
paraclinical criteria:
Effective contraception for women in age of pregnancy Written consent from patient or his/her legal representant, trustworthy person or family member Affiliated to a social security scheme
Exclusion criteria
Primary purpose
Allocation
Interventional model
Masking
133 participants in 2 patient groups
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Central trial contact
Giao DO-PHAM, MD
Data sourced from clinicaltrials.gov
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