Efficacy Study of CYT997 in Multiple Myeloma

Gilead Sciences

Status and phase

Terminated

Phase 2

Conditions

Relapsed and Refractory Multiple Myeloma

Treatments

Drug: CYT997

Study type

Interventional

Funder types

Industry

Identifiers

NCT00664378

CCL07001

Details and patient eligibility

About

This is a clinical research study that is designed to test the safety of CYT997 when given to patients with multiple myeloma and to test if CYT997 has any activity against that cancer.

Enrollment

5 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Diagnosis of multiple myeloma per International Working Group (IWG) criteria
Have received at least 1 but no more than 4 prior lines of therapy
Have failed to respond to the most recently administered anti-myeloma therapy
Have a life expectancy of at least 3 months
Eastern Cooperative Oncology Group (ECOG) performance status < 3
At registration absolute neutrophil count > 1x10^9/L and platelet count > 50 x 10^9/L unsupported
At registration bilirubin less than 1.5 x upper limit of normal and transaminases less than 2 x upper limit of normal and serum creatinine less than 0.19 mmol/L
Written informed consent
Must agree to adequate contraceptive measure if indicated

Exclusion criteria

Patients with monoclonal gammopathy of undetermined significance
Known or suspected hypersensitivity to CYT997
Patient with uncontrolled intercurrent illness
Active infections or other illnesses that precludes chemotherapy administration or patient compliance.
Pregnant or lactating women.
Patients who have received any other investigational agents in the last 3 weeks prior to the start of treatment.
Patients with the following conditions will be excluded:
- myocardial infarction or stroke within 6 months
- unstable angina pectoris or acute ischemic changes on ECG
- history of diabetic retinopathy
- symptomatic peripheral arterial disease
- major surgery in the last 30 days
Patients with uncontrolled diarrhea despite optimal medication and those with any history of acute gastrointestinal bleeding
Patients with a baseline prolongation of the QTc interval of Common Terminology Criteria (CTC) Grade 1 (QTc > 0.45-0.47 sec) or greater
Patients with impaired cardiac function or clinically significant cardiac diseases, including any one of the following:
- left ventricular ejection fraction (LVEF) < 45% as determined by multigated acquisition (MUGA) scan or echocardiogram;
- complete left bundle branch block;
- obligate use of a cardiac pacemaker;
- congenital long QT syndrome;
- history or presence of ventricular tachyarrhythmia;
- presence of unstable atrial fibrillation (ventricular response > 100 bpm). -Patients with stable atrial fibrillation are eligible, provided they do not meet any of the other cardiac exclusion criteria;
- clinically significant resting bradycardia (< 50 bpm);
- right bundle branch block + left anterior hemiblock (bifascicular block);
- angina pectoris ≤ 3 months prior to starting study drug;
- acute myocardial infarction (MI) ≤ 3 months prior to starting study drug; or
- other clinically significant heart disease (e.g., congestive heart failure (CHF), uncontrolled hypertension, history of labile hypertension, or history of poor compliance with an antihypertensive regimen).
Patients currently receiving treatment with medications known to prolong the QTc interval and/or to induce Torsades de Pointes arrhythmia.