Efficacy Study of Korean Red Ginseng to Treat Depression

Korea University

Status

Completed

Conditions

Major Depressive Disorder

Treatments

Dietary Supplement: Korean Red Ginseng

Study type

Interventional

Funder types

Other

Identifiers

NCT01496248

R1105721

Details and patient eligibility

About

The purpose of this study is to determine whether Korean Red Ginseng are effective in the treatment of the residual symptoms of depression as an adjuvant treatment.

Full description

Thirty-five female outpatients aging from 18 to 65 years, who were remitted from major depression with residual symptoms (Montgomery Asberg Depression Rating Scale, MADRS ≤ 12), were given Korean red ginseng at doses of 3g / day during 8 weeks.

Enrollment

35 patients

Sex

Female

Ages

18 to 55 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Outpatients who met Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria for major depressive disorder.
Those who are in remission, which is defined as a MADRS score 8 on two consecutive visits at a 4-week interval.
Their primary psychiatric clinician determined that they would benefit from an adjuvant treatment of Korean red ginseng for residual symptoms.

Exclusion criteria

Those who have a history of substance abuse or dependence within 1 month.
Those who have clinically significant abnormal laboratory values or any other abnormal baseline laboratory findings considered by psychiatrists to be indicative of conditions that might affect the study results.
Those who have a past history of hypersensitivity or intolerance to Korean red ginseng.
Those who participated in clinical trials within 1 month before entering the study entry.
Those who are pregnant or are breast feeding.
Those who have a immediate risk of harming self or others or history of suicide attempts in the year before the screening precluded inclusion in the study.
The patients unable/unlikely to comprehend/follow the protocol.