Efficacy Study of Transcranial Magnetic Stimulation for Treatment of Obsessive-Compulsive Disorder

University of Brasilia

Status and phase: Completed; Phase 2

Conditions: Obsessive Compulsive Disorder

Treatments: Device: Sham repetitive transcranial magnetic stimulation; Device: Repetitive Transcranial Magnetic Stimulation (rTMS)

Study type: Interventional

Funder types: Other

Identifiers

NCT01540305

49/09

Details and patient eligibility

About

This study aimed at verifying whether sessions of repetitive transcranial magnetic stimulation over a certain brain area (the supplementary motor area) could be useful in the relief of Obsessive-Compulsive Disorder symptoms.

Full description

Patients were randomly administered either real (n = 12) or sham (n = 10) rTMS, once a day, 5 days a week, for 2 weeks. Randomization was performed according to a computer-generated schedule. Subjects and scale-rater physician were blind to treatment status of individuals. Only the rTMS administrator was aware of group allocations. Treatment response was assessed by self-and clinician-rated scales before treatment, immediately after treatment and 3 months thereafter, with the same examiner following a subject throughout the study. All patients included in the study had failed adequate pharmacological treatment for at least 2 antiobsessional drugs. Their prescription drugs were continued without change in dosage regimens throughout the study.

Enrollment: 22 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age 18 to 60 years
• diagnosis of obsessive-compulsive disorder (OCD) according to DSM-IV-TR criteria and having OCD of at least moderate severity (YBOCS score of 16 or above).

Exclusion criteria

• subjects with comorbid psychiatric disorders (except depression - HAM-D ) or history of drug abuse
• significant head injury, or of any neurosurgical procedure
• pregnant women
• patients with metal implants or illnesses that prevent attendance to sessions
• patients with a history of seizure or bearing pacemakers

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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22 participants in 2 patient groups

Transcranial Magnetic Stimulation

Active Comparator group

Description:

Actual transcranial magnetic stimulation of supplementary motor areas bilaterally.

Treatment:

Device: Repetitive Transcranial Magnetic Stimulation (rTMS)

Sham Transcranial Magnetic Stimulation

Sham Comparator group

Description:

Sham transcranial magnetic stimulation over the supplementary motor areas.

Treatment:

Device: Sham repetitive transcranial magnetic stimulation