Efficacy Test on Skin Hydration and Skin Barrier Function

Cosmos Technical Center

Status: Completed

Conditions: Dry Skin

Treatments: Other: Pyridoxine tri-isopalmitate

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT01305057

hydration-1 (Other Identifier)

Cosmos1

Details and patient eligibility

About

The effects of topically applied pyridoxine tri-isopalmitate (P-IP) which stimulates filaggrin synthesis in keratinocytes, on skin hydration and barrier function were examined. Subjects were separated into two groups to examine the effect of P-IP. Subjects were treated with P-IP formulation on one side of the face and with a placebo formulation on the other side twice daily (morning and evening) for 28 days. All subjects gave written informed consent prior to the study. The skin hydration and TEWL (transepidermal water loss) were evaluated by measuring skin surface conductance with a skin hygrometer SKICON 200EX (I.B.S. ltd., Japan) and TEWL meter AS-CT1 (ASAHI BIOMED, Tokyo, Japan), respectively.

Full description

It is expected that the long-term application of P-IP increase skin surface water contents and suppress TEWL.

Enrollment: 20 patients

Sex: All

Ages: 33 to 62 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy skin

Exclusion criteria

• don't use any moisturizer

Trial design

Primary purpose: Health Services Research

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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20 participants in 1 patient group

Evaluation of P-IP on hydration and barrier function

Experimental group

Description:

Effects of P-IP on improvement of skin hydration and TEWL were examined.

Treatment:

Other: Pyridoxine tri-isopalmitate