Efficacy Transverse Abdominal Plane (TAP) Block Renal Transplant Surgery

Federal University of São Paulo

Status: Unknown

Conditions: Anesthesia, Conduction; Kidney Transplantation; Acute Pain; Renal Insufficiency, Chronic

Treatments: Procedure: TAP Block; Procedure: Saline Group

Study type: Interventional

Funder types: Other

Identifiers

NCT03181438

TAP Block Renal Transplant

Details and patient eligibility

About

The objective of this study is to evaluate the efficacy and safety of transverse abdominal plane block in patients undergoing renal transplant surgery.Adult renal transplant recipients will be prospectively randomized to receive a standard general anesthetic technique supplemented with ropivacaine 0.375% 20 mL TAP block or sham block with 20 mL 0.9% saline. Both groups will receive patient-controlled morphine analgesia. Patient assessment will occur in the postanesthetic care unit and at 1, 2, 4, 6, 12, and 24 hours. The primary outcome is total morphine consumption in the first 24 hours after renal transplantation. Other outcomes asses include pain scores, presence of nausea or vomiting, excessive sedation, and respiratory depression.

Enrollment: 42 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• end-stage renal disease undergoing cadaveric renal transplantation

Exclusion criteria

• Contraindications to the use of morphine
• Contraindications to the use ropivacaine
• Peripheral neuropathy
• Inability to use a Patient Control Analgesia device

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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42 participants in 2 patient groups

TAP Block

Experimental group

Description:

The TAP block will be performed under general anesthesia, according to the technique described below: * The patient will be placed supine with the abdomen exposed between the iliac crest and the costal margin * After skin antisepsis, a high-frequency ultrasound transducer will be placed transversely across the anterior axillary line above the iliac crest * In this region, the abdominal musculature (external oblique, internal oblique and transverse abdomen) is identified, and the transverse abdominal plane of the abdomen * The needle (BD-A-50mm) will be inserted in the technique "in plane" to the region of the transverse plane of the abdomen, where the solution will be administered. * In this group, will be administered 20 mL of 0.375% ropivacaine

Treatment:

Procedure: TAP Block

Saline Group

Sham Comparator group

Description:

The block will be performed under general anesthesia, according to the technique described below: * The patient will be placed supine with the abdomen exposed between the iliac crest and the costal margin * After skin antisepsis, a high-frequency ultrasound transducer will be placed transversely across the anterior axillary line above the iliac crest * In this region, the abdominal musculature (external oblique, internal oblique and transverse abdomen) is identified, and the transverse abdominal plane of the abdomen * The needle (BD-A-50mm) will be inserted in the technique "in plane" to the region of the transverse plane of the abdomen, where the solution will be administered. * In this group, will be administered 20 mL of Saline

Treatment:

Procedure: Saline Group