Efficiency of Manual Therapy on Central Sensitization in Patients With Nonspecific Chronic Back Pain

Atılım University

Status: Not yet enrolling

Conditions: Central Sensitization; Manual Therapy

Treatments: Other: conventional physiotherapy; Other: manual therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT05937503

E-59394181-604.01.02-33380

Details and patient eligibility

About

Central sensitization (CS) is defined as the increased responsiveness of nociceptive neurons in the central nervous system to normal or subthreshold afferent input. CS has been proposed as an underlying mechanism of chronic pain in musculoskeletal disorders including low back pain (LBP).

The aim of this study is to investigate the effect of manual therapy on central sensitization in patients with nonspecific chronic LBP.

Full description

A total of 40 LBP patients aged between 24-64 with CSS will be randomized into two groups. The manual therapy group will receive a 4-week manual therapy (two sessions/week) plus the conventional physiotherapy program, while the control group will only receive conventional physiotherapy. Before and after the interventions pain intensity (VAS), and scores of three questionnaires: Oswestry Disability Index (ODI), Central Sensitization Inventory (CSI), and the 36-item Short Form Health Survey Questionnaire (SF-36) will be recorded.The outcomes of the study will be analyzed by appropriate statistical methods.

Enrollment: 40 estimated patients

Sex: All

Ages: 20 to 64 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• non-spesific low back pain patients with pain longer than 12 weeks
• aged between 20-64 years male and female participants

Exclusion criteria

• concomitant disease that would interfere with treatment
• pregnancy
• have had any spinal surgery or fracture

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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40 participants in 2 patient groups

Manual therapy

Experimental group

Description:

Manual therapy group

Treatment:

Other: manual therapy

Other: conventional physiotherapy

Conventional physiotherapy

Other group

Description:

Conventional physiotherapy group

Treatment:

Other: manual therapy

Other: conventional physiotherapy