eHealth Mindfulness-based Music Therapy Intervention for Patients Undergoing Stem Cell Transplantation

University of Miami

Status: Enrolling

Conditions: Stem Cell Transplantation; Leukemia, Myeloid, Acute; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Non-Hodgkin; Myelodysplastic Syndromes

Treatments: Behavioral: eHealth Mindfulness-based Music Therapy (eMBMT); Behavioral: eHealth Mindfulness Meditation (eMM)

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT07469592

R33CA263335 (U.S. NIH Grant/Contract)

20250732

Details and patient eligibility

About

The goal of this study is to test an electronic health (eHealth) mindfulness-based music therapy intervention to improve health-related quality of life and reduce symptom burden and disease activity in patients undergoing stem cell transplantation.

Enrollment: 165 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ≥ 18 years of age
• have a primary diagnosis of a hematologic malignancy (e.g., myelodysplastic syndrome [MDS], acute myeloid leukemia [AML], acute lymphoblastic leukemia [ALL], or non Hodgkin's Lymphoma [NHL])
• have a treatment plan for a hematopoietic stem cell transplant
• Speak English or Spanish

Exclusion criteria

• history of severe psychiatric illness (e.g., psychosis, active suicidality, inpatient treatment in the past 12 months)
• severe cognitive impairment (per the short portable mental status questionnaire)
• hearing impairment
• active alcohol or substance dependence within the past six months
• participated in the prior pilot MBMT R61 phase
• participated in music therapy or mindfulness programs in the past six months

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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165 participants in 2 patient groups

eHealth Mindfulness-based Music Therapy (eMBMT)

Experimental group

Description:

Participants will be in the MBMT group for 5 months.

Treatment:

Behavioral: eHealth Mindfulness-based Music Therapy (eMBMT)

eHealth Mindfulness Meditation (eMM)

Experimental group

Description:

Participants will be in the MM group for 5 months.

Treatment:

Behavioral: eHealth Mindfulness Meditation (eMM)