Elasticity of the Hoffa's Fat Pad in Patients With Knee Osteoarthritis


Taipei Veterans General Hospital




Elasticity Imaging Techniques
Knee Osteoarthritis

Study type


Funder types




Details and patient eligibility


Knee osteoarthritis (OA) is a common problem in clinical settings. Knee OA is well known for its association with the wear and tear of the cartilage and osteophyte formation. Evidence has suggested the importance of the infrapatellar fat pad, known as Hoffa's fat pad, during the development of knee OA. Some studies have demonstrated the protective role of the infrapatellar fat pad, whereas others have suggested an inflammatory role such as increased fibrosis and proinflammatory cytokine levels. Ultrasound is exceptionally convenient in the assessment of the musculoskeletal system, and elastography is a tool to evaluate tissue texture. Therefore, in this study, we investigated the Hoffa's fat pad in knee OA patients by using elastography.

Full description

This was an observation study that included a control group. We enrolled 20 patients with knee OA, as well as 10 healthy individuals. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Kellgren-Lawrence X-ray grading were employed to determine disease severity. All the study participants received elastography assessment, including strain and shear wave elastography in the knee extension and flexion position. The strain elastography contained color mapping that enabled the calculation of the relative texture and strain ratio. The shear wave elastography revealed the qualitative velocity, which was measured 3 times. Each patients with knee OA received elastography examination twice: once before hyaluronic acid injection and once 1 month after the injection.


33 patients




20 to 86 years old


Accepts Healthy Volunteers

Inclusion criteria

OA group

  • Kellgren-Lawrence grading I-IV proved by knee X-ray Healthy group
  • No knee pain or received injection during the past 1 year
  • No history of knee OA

Exclusion criteria

  • History of knee surgery, trauma or malignancy
  • History of patellar tendinopathy or patellofemoral pain syndrome
  • Refused informed consent

Trial design

33 participants in 2 patient groups

knee osteoarthritis group
individuals being diagnosed with osteoarthritis and classified by K-L grading
healthy group
individuals without knee pain or diagnosis of knee osteoarthritis

Trial contacts and locations



Data sourced from clinicaltrials.gov

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