Elderly Patients Undergoing Surgery During Perioperative Period

Second Affiliated Hospital of Wenzhou Medical University

Status: Enrolling

Conditions: Postoperative Complications; Postoperative Delirium (POD); Pathogenesis; Elderly; Risk Prediction Model

Study type: Observational

Funder types: Other

Identifiers

NCT07314762

SAHoWMU-CR2025-03-231

Details and patient eligibility

About

The elderly patients have poorer overall conditions and have lower tolerance to trauma, anesthesia, and surgery. Therefore, the incidence of postoperative complications is relatively higher. In non-cardiac surgeries, approximately 20% of elderly patients experience postoperative complications, and the incidence of postoperative delirium (POD) is 23.8%. This may lead to prolonged hospital stays, increased hospital costs, and affect prognosis and even mortality. The investigators plan to conduct a prospective cohort study by systematically collecting biological samples and clinical information of elderly patients during the perioperative period to explore the possible risk factors and pathogenesis of postoperative delirium and postoperative complications in elderly surgical patients, and to construct a risk prediction model for postoperative complications.

Enrollment: 1,200 estimated patients

Sex: All

Ages: 65+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1) Surgical patients aged 65 or above or non-surgical subjects aged 65 or above. 2) Agree to participate in this study and sign the informed consent form.

Exclusion criteria

1）Refused to participate in the study.

Trial design

1,200 participants in 2 patient groups

Surgical patients aged 65 years or older

Description:

For the surgical group patients, questionnaires and scales measuring cognitive function, sleep quality, and quality of life were collected preoperatively, at 1-7 days post-operation, 30 days post-operation, and 1 year post-operation. During the operation, blood, cerebrospinal fluid, and other biological samples from the patients were also collected.

non-surgical subjects aged 65 years or older

Description:

For the non-surgical group patients, patients' basic information was collected, along with cognitive scales, sleep scales, and quality of life questionnaires.