Electrical Impedance Tomography-Based Prognostic Model for ARDS

XiaoJing Zou,MD

Status: Enrolling

Conditions: Acute Respiratory Distress Syndrome (ARDS); Ventilator-induced Lung Injury

Treatments: Other: Not applicable- observational study

Study type: Observational

Funder types: Other

Identifiers

NCT06967207

EIT20250331

Details and patient eligibility

About

This multicenter, prospective, observational study aims to develop and validate an EIT-based prognostic model for ARDS. By focusing on the pathophysiological characteristics of ARDS and the causes of ventilator-induced lung injury, the investigators intend to establish a prognostic model that reveals lung injury and heterogeneity, enabling risk stratification and guiding individualized treatment.

Enrollment: 625 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Meet the new 2023 ARDS global definition;
2. Age 18-80 years

Exclusion criteria

1. Expected death within 24 hours of screening;
2. Metastatic cancer (active malignancy with distant metastases);
3. Severe psychiatric disorders;
4. Pregnancy or postpartum status;
5. Pneumothorax or moderate to large pleural effusion without adequate drainage;
6. Chronic respiratory failure;
7. Patients with pulmonary embolism or pulmonary hypertension;
8. Heart failure patients: EF <50% or NYHA class III or IV;
9. Patient/family refusal to participate;
10. Participation in another interventional trial within 3 months prior to enrollment

Trial design

625 participants in 2 patient groups

ARDS Patients for Training cohort

Description:

Training cohort

Treatment:

Other: Not applicable- observational study

ARDS Patients for Validation cohort

Description:

Validation cohort

Treatment:

Other: Not applicable- observational study