Electrical Impulse Parameters and Neuronal Population in the Cochlear Implanted Patient-PULSE

Regional University Hospital Center (CHRU)

Status: Not yet enrolling

Conditions: Sensorineural Hearing Loss

Treatments: Other: Cochlear implant (Oticon) stimulation parameter optimization

Study type: Interventional

Funder types: Other

Identifiers

NCT06013215

DR230050-PULSE

DR230050 (Registry Identifier)

2023-A00476-39 (Other Identifier)

Details and patient eligibility

About

The cochlear implant provides good auditory performance despite high inter-individual variability, but performance in noise remains limited. Modification of the coding strategies could improve these performances. A better characterization of the remaining neuronal population by looking for the charge integration efficiency (which depends on the duration and the amplitude of the electrical pulse) would allow an optimization of the settings by adapting either the duration or the amplitude of the pulse according to the quality of the remaining neuronal population.

Full description

The cochlear implant provides good auditory performance despite high inter-individual variability, but performance in noise remains limited. Modification of the coding strategies could improve these performances. Currently, the intensity perceived by the patient is coded by the duration and the amplitude of the electrical impulse but companies have different approaches and fix one of the two parameters for the setting of the processors. A better characterization of the remaining neuronal population by looking for the charge integration efficiency (which depends on the duration and the amplitude of the electrical pulse) would allow an optimization of the settings by adapting either the duration or the amplitude of the pulse according to the quality of the remaining neuronal population.

Enrollment: 15 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• post-lingually deaf adults with at least one year of cochlear implant experience
• unilateral and bilateral cochlear implant recipients
• Oticon device with Neuro Zti array
• Patient affiliated to french social security
• Consent signed

Exclusion criteria

• Patients under court protection, guardianship or curatorship

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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15 participants in 1 patient group

Cochlear implant users with Neuro Zti array

Experimental group

Description:

Post-lingually cochlear implant users with 12 months of auditory experience Modifications of pulse parameters to determine the charge integration efficiency which is related with neuron survival population

Treatment:

Other: Cochlear implant (Oticon) stimulation parameter optimization