Electrical Stimulation Combined With Motor Training on EEG-EMG Coherence and Motor Function in Individuals With Stroke

National Yang Ming Chiao Tung University

Status: Completed

Conditions: Stroke

Treatments: Other: Electrical stimulation; Other: Sham electrical stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT03277534

104-2314-B-010-024

Details and patient eligibility

About

This study investigated whether electrical stimulation (ES) prior to a hand function training session for a total of eight weeks can better improve neuromuscular control and hand function in subacute stroke individuals and change electroencephalography-electromyography (EEG-EMG) coherence, as compared to the control (sham ES).

Full description

Subjects were randomly assigned into ES and control groups. Both groups received 20-minute hand function training twice a week, and the ES group received 40-minute ES on the median nerve of the affected side before each training session. The control group received sham ES - electrodes were placed on the same location but no electric current was applied. EEG, EMG and Fugl-Meyer Assessment (FMA) were collected before, at the 4th week, at the end of 8th week, and 4 weeks after the end of intervention.

Enrollment: 12 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. first-ever cerebral cortical region involved chronic stroke, onset over a month,
2. able to perform active thumb flexion on the affected side with the scores of manual muscle test at least two points, and
3. at stable medical condition for intervention

Exclusion criteria

1. history of other neurological disorders,
2. cognitive impairment (Mini-Mental State Examination score <24, MMSE),26
3. unable to follow orders,
4. contraindications of ES, and
5. under 20 years old

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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12 participants in 2 patient groups

Electrical stimulation

Experimental group

Treatment:

Other: Electrical stimulation

Control

Sham Comparator group

Treatment:

Other: Sham electrical stimulation